Study of Role of Collagen in Healing Chronic Wounds

M M Ram Shankar; M B Satyaveni

M M Ram Shankar Army College of Medical Sciences and Base Hospital, New Delhi, India
M B Satyaveni Al Falah College of Medical Sciences Research Centre and Hospital,Dhauj Faridabad, Haryana, India

Keywords: Bovine native collagen, Chronic ulcer, Gangrene, Matrix metalloproteinase enzyme, Matrix metalloproteinases

Abstract

Aim: To study the role of collagen in healing of chronic wounds. Materials and Methods: One hundred and twelve patients aged between 25 and 65 years were studied. The etiology of chronic wounds was as follows: 38 (33.9%) were diabetic, 33 (29.4%) had venous wound, 4 (3.57%) had arterial, 19 (16.9%) had trophic, 3 (2.67%) had tubercular, and 15 (13.3%) had traumatic wounds, and complications were as follows: 8 (12.6%) had gangrene, 19 (30%) had sloughing and exposure to tendon, 27 (42.8%) had eczema and dermatitis, 3 (4.76%) had bony changes, 2 (3.17%) had hemorrhages, and 4 (6.34%) had subcalcification of wound Results: Organisms isolated from the wounds were as follows: 46 (41%) had Staphylococcus aureus , 12 (10.7%) had Streptococcus pyogenes , 15 (13.3%) had Escherichia coli , 7 (6.25%) had Klebsiella, 11 (9.82%) had Proteus mirabilis , and 21 (18.7%) had sterile (no organism). Conclusions: This pragmatic approach to chronic wounds having different etiologies and pathophysiologic conditions will be useful to surgeon to treat such patients efficiently because healing of chronic wounds without amputation (limb saving) is a great medical challenge globally.

Author Biographies

M M Ram Shankar, Army College of Medical Sciences and Base Hospital, New Delhi, India

Assistant Professor, Department of Surgery,

M B Satyaveni, Al Falah College of Medical Sciences Research Centre and Hospital,Dhauj Faridabad, Haryana, India

Senior
Resident, Department of Obstetrics and Gynecology,