Significance of Expression of PSP94 Isoforms in Etiology of Benign Prostatic Hyperplasia and Prostate Cancer

  • Deepa R Mhatre Seth GS Medical College & KEM Hospital,Mumbai - 400 012, Maharashtra, India
  • Smita D Mahale National Institute for Research in ReproductiveHealth, Jehangir Merwanji Street, Parel, Mumbai, India
  • Jayesh V Dhabalia Seth GS MedicalCollege & KEM Hospital, Parel, Mumbai, India
  • Hemant B Tongaonkar TataMemorial Hospital, Parel, Mumbai, India
  • Gwendolyn C Fernandes Seth GS Medical College & KEMHospital, Parel, Mumbai, India
  • Sucheta P Dandekar Seth GS MedicalCollege & KEM Hospital, Parel, Mumbai, India
  • Anand M Varadkar Seth GSMedical College & KEM Hospital, Parel, Mumbai, India
Keywords: Benign Prostatic Hyperplasia, Prostate Cancer, PSP94 (MSMB1), PSP57 (MSMB2)

Abstract

Background: Prostate Secretory Protein of 94 Amino Acids (PSP94) level is known to increase in benign prostatic hyperplasia
(BPH) and decrease in prostate cancer (PCa). However, there has not been a consensus on the abundance and significance of
the different isoforms of PSP94 during the development of BPH and PCa. Methods: Benign and malignant prostate tissue was ascertained histologically. Biplex polymerase chain reaction (PCR) and real-time PCR were employed to quantitate the two isoforms, PSP94 (MSMB1) and PSP57 (MSMB2). Results: Higher abundance of both MSMB1 and MSMB2 transcripts was observed in BPH as compared to PCa. Further, there was a strong positive correlation between the transcript levels of these isoforms, MSMB1 and MSMB2, in samples from both BPH and PCa patients Conclusions: PSP57 (MSMB2) transcript may not be involved in the development of BPH or PCa and could have a physiological role in prostate cells.

Author Biographies

Deepa R Mhatre, Seth GS Medical College & KEM Hospital,Mumbai - 400 012, Maharashtra, India

Department of Biochemistry and Clinical Nutrition

Smita D Mahale, National Institute for Research in ReproductiveHealth, Jehangir Merwanji Street, Parel, Mumbai, India

Scientist G and Director, Division of Structural Biology

Jayesh V Dhabalia, Seth GS MedicalCollege & KEM Hospital, Parel, Mumbai, India

Professor and Head, Department of Urology

Hemant B Tongaonkar, TataMemorial Hospital, Parel, Mumbai, India

Professor and Head, Department of Genitourinary Oncology

Gwendolyn C Fernandes, Seth GS Medical College & KEMHospital, Parel, Mumbai, India

Associate Professor, Department of Pathology

Sucheta P Dandekar, Seth GS MedicalCollege & KEM Hospital, Parel, Mumbai, India

Professor and Head, Department of Biochemistry and Clinical Nutrition

Anand M Varadkar, Seth GSMedical College & KEM Hospital, Parel, Mumbai, India

Professor, Department of Biochemistry and Clinical Nutrition

Published
2015-05-30