Nicolau Syndrome – “Penalty for the Pain Killer:” A Review Article
Nicolau syndrome, also called embolia cutis medicamentosa (ECM), is an infrequent complication following intramuscular and
intra-articular injection of various drugs. This rare entity is characterized by severe pain and erythematous-ecchymotic reticular
lesions, which in many cases lead to necrotic ulcers and scarring. Clinicians must be cautious in the use of proper injection
procedures, including appropriate needle length, to minimize complications.
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