Application of Platelet-rich Plasma in Androgenic Alopecia and in Female Pattern Hair loss
Aim: The aim of the study was to evaluate the efficacy of platelet-rich plasma (PRP) injections in Androgenic Alopecia (AGA)
and female pattern hair loss.
Settings and Design: A prospective clinical trial consisting of ten patients with AGA was undertaken in the institutional settings,
where each patient was treated with intradermal injections of PRP, after the approval from the institutional ethical committee.
Materials and Methods: Patients suffering from hair loss were assessed preoperatively using hair-pull test and dermascopic
examination to evaluate the number of hair follicles and anagen-telogen ratio. Digital pictures of the scalp were recorded before
the treatment. PRP was isolated from blood and approximately 2–3 ml was injected in deficient regions in the patients, using
nappage technique. A patient satisfactory questionnaire was recorded at the end of the treatment. Results at the end of 6 months
were evaluated and statistical analysis was done.
Results: Decrease in the hair-pull test before and after the treatment was statistically significant (mean = −6.40; P = 0.000). The
increase in the total dermascopic hair count and anagen-telogen ratio of all the regions of the scalp, when assessed before and
after the treatment was statistically significant (mean = 87.50 and 6.27, respectively; P = 0.001 and 0.000, respectively). The
patient satisfaction score was 8.1 out of 10.
Conclusions: PRP is a cost-effective, easy and reliable therapy, with negligible side effects and very high patient satisfaction. It
has proved to be a valuable treatment option in patients suffering from AGA.
Key Messages: The injections of PRP in androgen affected regions of scalp in men and deficient regions in female, gives excellent
results of increased hair density with reduced hair fall, in all the regions of the scalp with specifically significant difference seen
in vertex region of scalp in our study
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