Comparative Study between Collagen Dressings and Conventional Dressings in Chronic Leg Ulcers
Background: Chronic leg ulcer is defined as a non-healing or slow disintegration of epidermal and dermal tissue on the legs that last longer than 6 weeks. The majority of these ulcers are associated with venous disease, peripheral vascular disease, peripheral arterial occlusive disease, diabetes, nutritional factors, or metabolic factors like uremia. Collagen sheet is a material that is suitable for use as an allograft in wound healing. It is employed in sheets, membranes, and sponge forms; later, in preserved preparations, the material aids in the healing process by promoting regenerative healing while lowering scar formation through several properties such as physical, biochemical, and molecular biological pathways.
Materials and Methods: Study Design: A prospective follow-up study. Study Duration: One year from March 2, 2019, to March 1, 2020, at the time of Institutional Ethics Committee approval. Source of Data: Cases admitted in general surgery wards in S.V.R.R.G.G. Hospital, Tirupati. Sample Size: 100 patients.
Results: The mean rate of the percentage of reduction ulcer size was higher in the study group than in the control group. The Chi-square test results were analyzed, which showed a highly significant difference in the percentage of ulcer size (P < 0.0001). The total number of days in the hospital for the patient to stay is compared. The mean number of days of hospital stay in the control group was 18 days and that in the study group was 14 days. The results were analyzed by the Chi-square test, which showed a significant difference in the number of days of hospital stay. The total number of dressings required for complete wound healing with collagen dressing was 5.88 compared to conventional which was 11; t-test shows the significance. The rate of ulcer healing with the collagen group was 3.58 compared to the conventional group which was 4.66, t-test shows high significance.
Conclusion: Collagen dressing increases the rate of wound healing as compared to conventional dressings. Collagen dressings could be used to treat chronic non-healing leg ulcers.
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