Assessment of the Relationship between the Presence of Helicobacter pylori Infection and Cholelithiasis
Introduction: Helicobacter pylori is a gram-negative, micro-aerophilic bacteria commonly persisting in the stomach lining. This
study aims to detect a possible relationship between H. pylori colonization of the stomach and the occurrence of cholelithiasis.
Materials and Methods: This is a cross-sectional study carried out in the Department of General Surgery, Saveetha Medical
College and Hospital, Chennai from January 2021 to April 2021. Patients who presented to the Surgery OPD with complaints
of abdominal pain were asked to undergo diagnostic endoscopy and ultrasound (USG). A sample size of 53 patients tested
positive for H. pylori infection in the rapid urease test following diagnostic endoscopy. A thorough history was elicited from the
patients who fit the above criteria. Subsequently, a positive finding of H. pylori in the biopsy was correlated with the presence of
cholelithiasis in the USG.
Results: The study population included 21 female and 32 male patients. A large percentage of the study population (39%) belonged
to the age group 51–60 years. Among the study population, only four out of the 53 patients were found to have cholelithiasis
based on abdominal USG findings. This indicates that cholelithiasis was present in only 7.55% of the study population. Among
the four patients with cholelithiasis, only one was a female patient and the remaining three were male patients. There was no
significant sex difference in the occurrence of cholelithiasis in H. pylori-positive patients.
Conclusion: From this study, we conclude that there was no significant relationship between H. pylori colonization of the stomach
and the occurrence of cholelithiasis as only four out of 53 patients had both H. pylori Infection and Cholelithiasis.
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