Assessment of the Relationship between the Presence of Helicobacter pylori Infection and Cholelithiasis

  • Touzeen Hussain Assistant Professor, Department of General Surgery
  • Kavya S MBBSStudent, Saveetha Medical College
Keywords: Cholelithiasis, Diagnostic endoscopy, Helicobacter pylori

Abstract

Introduction: Helicobacter pylori is a gram-negative, micro-aerophilic bacteria commonly persisting in the stomach lining. This
study aims to detect a possible relationship between H. pylori colonization of the stomach and the occurrence of cholelithiasis.
Materials and Methods: This is a cross-sectional study carried out in the Department of General Surgery, Saveetha Medical
College and Hospital, Chennai from January 2021 to April 2021. Patients who presented to the Surgery OPD with complaints
of abdominal pain were asked to undergo diagnostic endoscopy and ultrasound (USG). A sample size of 53 patients tested
positive for H. pylori infection in the rapid urease test following diagnostic endoscopy. A thorough history was elicited from the
patients who fit the above criteria. Subsequently, a positive finding of H. pylori in the biopsy was correlated with the presence of
cholelithiasis in the USG.
Results: The study population included 21 female and 32 male patients. A large percentage of the study population (39%) belonged
to the age group 51–60 years. Among the study population, only four out of the 53 patients were found to have cholelithiasis
based on abdominal USG findings. This indicates that cholelithiasis was present in only 7.55% of the study population. Among
the four patients with cholelithiasis, only one was a female patient and the remaining three were male patients. There was no
significant sex difference in the occurrence of cholelithiasis in H. pylori-positive patients.
Conclusion: From this study, we conclude that there was no significant relationship between H. pylori colonization of the stomach
and the occurrence of cholelithiasis as only four out of 53 patients had both H. pylori Infection and Cholelithiasis.

Author Biographies

Touzeen Hussain, Assistant Professor, Department of General Surgery

Saveetha Medical College, Chennai, Tamil Nadu, India

Kavya S, MBBSStudent, Saveetha Medical College

Chennai, Tamil Nadu, India

References

1. Athavale VS, Khandalkar SN, Bhide PC, Shetty I,
Lad A. A study of association of H. pylori infection and
cholelithiasis. Int Surg J 2018;5:701-4.
2. Kusters JG, Van Vliet AH, Kuipers EJ. Pathogenesis
of Helicobacter pylori infection. Clin Microbiol Rev
2006;19:449-90.
3. Calvet X, Ramírez Lázaro MJ, Lehours P, Mégraud F.
Diagnosis and epidemiology of Helicobacter pylori infection.
Helicobacter 2013;18:5-11.
4. Peña-Galo E, Gotor J, Harb Y, Alonso M, Alcedo J.
Socioeconomic and demographic factors associated with
failure in Helicobacter pylori eradication using the standard
triple therapy. Gastroenterol Hepatol From Bed Bench
2021;14:53.
5. Belzer C, Kusters JG, Kuipers EJ, Van Vliet AH. Urease
induced calcium precipitation by helicobacter species may
initiate gallstone formation. Gut 2006;55:1678-9.
6. Zhou D, Zhang Y, Gong W, Mohamed SO, Ogbomo H,
Wang X, et al. Are Helicobacter pylori and other helicobacter
species infection associated with human biliary lithiasis? A
meta-analysis. PLoS One 2011;6:e27390.
7. Ari A, Tatar C, Yarikkaya E. Relationship between
Helicobacter pylori-positivity in the gallbladder and stomach
and effect on gallbladder pathologies. J Int Med Res
2019;47:4904-10.
8. Zhang FM, Yu CH, Chen HT, Shen Z, Hu FL, Yuan XP, et al.
Helicobacter pylori infection is associated with gallstones:
Epidemiological survey in China. World J Gastroenterol
2015;21:8912.
9. Helaly GF, El-Ghazzawi EF, Kazeiw AH, Dowidar NL,
Anwar MM, Attia NM. Detection of Helicobacter pylori
infection in Egyptian patients with chronic calcular
cholecystitis. Br J Biomed Sci 2014;71:13-8.
10. Attaallah W, Yener N, Ugurlu MU, Manukyan M, Asmaz E,
Aktan AO. Gallstones and concomitant gastric Helicobacter
pylori infection. Gastroenterol Res Pract 2013;2013:643109.
11. Gunasekaran P, Vinson I. Helicobacter pylori colonization of
gallbladder in patients with symptomatic cholelithiasis. Int
Surg J 2017;4:2194-6.
12. Zhou D, Guan WB, Wang JD, Zhang Y, Gong W, Quan ZW.
A comparative study of clinicopathological features
between chronic cholecystitis patients with and without
Helicobacter pylori infection in gallbladder mucosa. PLoS
One 2013;8:e70265.
13. Wang L, Chen J, Jiang W, Cen L, Pan J, Yu C, et al. The
relationship between Helicobacter pylori infection of the
gallbladder and chronic cholecystitis and cholelithiasis:
A systematic review and meta-analysis. Can J Gastroenterol
Hepatol 2021;2021:8886085.
14. Woodward M, Morrison C, McColl K. An investigation into
factors associated with Helicobacter pylori infection. J Clin
Epidemiol 2000;53:175-81.
15. Ibrahim A, Morais S, Ferro A, Lunet N, Peleteiro B. Sexdifferences
in the prevalence of Helicobacter pylori infection
in pediatric and adult populations: Systematic review and
meta-analysis of 244 studies. Digest Liver Dis 2017;49:742-9.
16. Valliani A, Khan F, Chagani B, Khuwaja AK, Majid S,
Hashmi S, et al. Factors associated with Helicobacter pylori
infection, results from a developing country-Pakistan. Asian
Pac J Cancer Prev 2013;14:53-6.
17. Chapman BA, Frampton CM, Wilson IR, Chisholm RJ,
Allan RB, Burt MJ. Gallstone prevalence in Christchurch: Risk
factors and clinical significance. N Zeal Med J 2000;113:46.
18. Everhart JE, Khare M, Hill M, Maurer KR. Prevalence and
ethnic differences in gallbladder disease in the United
States. Gastroenterology 1999;117:632-9.
19. Nakeeb A, Comuzzie AG, Martin L, Sonnenberg GE, Swartz-
Basile D, Kissebah AH, et al. Gallstones: Genetics versus
environment. Ann Surg 2002;235:842.
20. Monstein HJ, Jonsson Y, Zdolsek J, Svanvik J. Identification
of Helicobacter pylori DNA in human cholesterol gallstones.
Scand J Gastroenterol 2002;37:112-9.
Published
2021-09-23
Section
Articles