Use of Modafi nil for Shortening the Recovery Period of Patients Subjected to Conscious Sedation

  • Dr. Harsh Rajvanshi Manipal University, Karnataka, India
  • Raghav Ahuja I.T.S Centre for Dental Studies and Research, Muradnagar, Uttar Pradesh,India
  • Alok Bhatnaga S.G.T Dental College, Gurgaon, New Delhi, India
  • Kumar Anshu Manipal College of Dental Sciences, Manipal, Karnataka, India
  • Rupinder Kaur Brar Manipal College of Dental Sciences, Manipal, Karnataka, India
Keywords: Conscious sedation, Flumazenil, Modafi nil, Naloxone, Recovery

Abstract

Conscious sedation is a safe and effective technique for patients subjected to invasive diagnostic procedures or minor surgeries. One of the most common seen side effects of this procedure involves Drowsiness, which may be so severe that the patient is not able and advised to resume his normal day to day activities up to 24 h post procedure. This amount of time in recovery is discomforting to the patient and thus should be reduced to a bare minimum following analgesic action of the sedatives. The mechanisms of action of all major classes of sedatives follow a common route via stimulation of gamma amino butyric acid (GABA) receptors along with depression in the release of dopamine, which controls locomotor activity. Modafi nil leads to increase in extracellular and synaptic concentrations of dopamine, elevates hypothalamic histamine levels and also causes activation of glutamatergic circuits, while inhibiting GABAergic neurotransmission. The objective of this short communication was to search for a universal agent to facilitate the recovery post conscious sedation and to determine the role of Modafi nil for the same. At the end, we hypothesized that modafi nil can act as a reliable universal drug to shorten the recovery period of patients subjected to procedural anesthesia.

Author Biographies

Dr. Harsh Rajvanshi, Manipal University, Karnataka, India

PG, Department of Public Health

Raghav Ahuja, I.T.S Centre for Dental Studies and Research, Muradnagar, Uttar Pradesh,India

BDS, Department of Public Health Dentistry

Alok Bhatnaga, S.G.T Dental College, Gurgaon, New Delhi, India

Reader, Department of Oral and
Maxillofacial Surgery

Kumar Anshu, Manipal College of Dental Sciences, Manipal, Karnataka, India

Intern, Department of Oral and Maxillofacial
Surgery

Rupinder Kaur Brar, Manipal College of Dental Sciences, Manipal, Karnataka, India

Intern, Department of Oral and Maxillofacial
Surgery

Published
2015-05-30